A tetrahydrobenzofuran derivative from the fermentation broth of Lentinus squarrosulus BCC 22366

A new tetrahydrobenzofuran derivative, (6S,7S)-6,7-dihydroxy-3,6-dimethyl-2-isovaleroyl-4,5,6,7-tetrahydrobenzofuran (1), together with the known 1,2-dihydroxymintlactone (2), was isolated from the fermentation broth of the edible mushroom fungus Lentinus squarrosulus BCC 22366. The structure was elucidated by interpretation of NMR spectroscopic and mass spectrometry data. The absolute configuration of 1 was addressed by application of the modified Mosher's method.