Enantioselective Synthesis of Protected Amines by the Catalytic Asymmetric Addition of Hydrazoic Acid to Ketenes

A-mine of possibilities: An effective method for the conversion of achiral ketenes into enantioenriched protected amines was developed by tuning the structure and reactivity of a catalyst on the basis of a mechanistic hypothesis. The method involved the catalytic asymmetric addition of hydrazoic acid to ketenes, followed by a Curtius rearrangement (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700697_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.