化学
二甲基过氧化酮
羟基化
有机化学
催化作用
对映选择合成
分子氧
组合化学
酶
作者
Jens Christoffers,Angelika Baro,Thomas Werner
标识
DOI:10.1002/adsc.200303140
摘要
Abstract The most convenient and direct route to α‐hydroxy‐β‐dicarbonyl compounds is the oxidation of readily accessible 1,3‐dicarbonyls. Hence, this type of oxidation is an intensively investigated field. In this short review, we present and compare α‐hydroxylations using various oxidants such as peracids (Rubottom oxidation), dimethyldioxirane or molecular oxygen. From an economical and ecological point of view, metal‐catalyzed air oxidations are optimal at least for cyclic β‐dicarbonyls. For asymmetric α‐hydroxylations only chiral sulfonyloxaziridines are available to date. Thus, there is still a need for significant development in this area.
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