Real-time magnetic resonance-guided laser thermal therapy for focal metastatic brain tumors.

医学 磁共振成像 放射外科 放射治疗 放射科 烧蚀 病变 核医学 外科 内科学
作者
Alexandre Carpentier,Roger J. McNichols,R. Jason Stafford,Julian Itzcovitz,J.-P. Guichard,D Reizine,Suzette Delaloge,Éric Vicaut,Didier Payen,Ashok Gowda,Bernard George
出处
期刊:PubMed 卷期号:63 (1 Suppl 1): ONS21-9 被引量:208
标识
DOI:10.1227/01.neu.0000335007.07381.df
摘要

We report the initial results of a pilot clinical trial exploring the safety and feasibility of the first real-time magnetic resonance-guided laser-induced thermal therapy of treatment-resistant focal metastatic intracranial tumors.Patients with resistant metastatic intracranial tumors who had previously undergone chemotherapy, whole-brain radiation therapy, and radiosurgery and who were recused from surgery were eligible for this trial. Under local anesthesia, a Leksell stereotactic head frame was used to insert a water-cooled interstitial fiberoptic laser applicator inside the cranium. In the bore of a magnetic resonance imaging (MRI) scanner, laser energy was delivered to heat the tumor while continuous MRI was performed. A computer workstation extracted temperature-sensitive information to display images of laser heating and computed estimates of the thermal damage zone. Posttreatment MRI scans were used to confirm the zone of thermal necrosis, and follow-up was performed at 7, 15, 30, and 90 days after treatment.In all cases, the procedure was well tolerated without secondary effect, and patients were discharged to home within 14 hours after the procedure. Follow-up imaging showed an acute increase in apparent lesion volume followed by a gradual and steady decrease. No tumor recurrence within thermal ablation zones was noted.In this ongoing trial, a total of four patients have had six metastatic tumors treated with laser thermal ablations. Magnetic resonance-guided laser-induced thermal therapy appears to provide a new, efficient treatment for recurrent focal metastatic brain disease. This therapy is a prelude to the future development of closed-head interventional MRI techniques in neurosurgery.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
蔷薇完成签到,获得积分10
5秒前
开放映冬完成签到,获得积分10
5秒前
qinghong发布了新的文献求助10
6秒前
顾矜应助下雨这天采纳,获得10
6秒前
大胆的忆安完成签到 ,获得积分10
7秒前
创新完成签到 ,获得积分10
9秒前
abc完成签到 ,获得积分10
9秒前
13秒前
CipherSage应助CC采纳,获得10
14秒前
qinghong完成签到,获得积分10
15秒前
沉静智宸完成签到 ,获得积分10
16秒前
16秒前
花蝴蝶完成签到 ,获得积分10
18秒前
xuli-888完成签到,获得积分10
18秒前
car子完成签到 ,获得积分10
20秒前
Jes发布了新的文献求助30
20秒前
畅快的长颈鹿完成签到,获得积分10
26秒前
26秒前
克泷完成签到 ,获得积分10
30秒前
共享精神应助阿司匹林采纳,获得10
30秒前
坚强的蚂蚁完成签到,获得积分10
31秒前
Vivian完成签到,获得积分10
32秒前
脑洞疼应助雪山飞龙采纳,获得10
35秒前
健康的修洁完成签到 ,获得积分10
36秒前
36秒前
39秒前
CCC完成签到 ,获得积分10
46秒前
嗨Honey完成签到 ,获得积分10
48秒前
超chao完成签到,获得积分10
49秒前
糊涂的麦片完成签到,获得积分10
50秒前
Wind发布了新的文献求助20
51秒前
sylens完成签到,获得积分10
51秒前
科研通AI5应助张先生采纳,获得10
52秒前
昔年完成签到 ,获得积分10
53秒前
小全完成签到,获得积分10
54秒前
56秒前
香菜大王完成签到 ,获得积分10
56秒前
59秒前
Jro完成签到,获得积分10
59秒前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Continuum Thermodynamics and Material Modelling 2000
Encyclopedia of Geology (2nd Edition) 2000
105th Edition CRC Handbook of Chemistry and Physics 1600
Maneuvering of a Damaged Navy Combatant 650
Периодизация спортивной тренировки. Общая теория и её практическое применение 310
Mixing the elements of mass customisation 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3779565
求助须知:如何正确求助?哪些是违规求助? 3325025
关于积分的说明 10221059
捐赠科研通 3040157
什么是DOI,文献DOI怎么找? 1668640
邀请新用户注册赠送积分活动 798728
科研通“疑难数据库(出版商)”最低求助积分说明 758522