同源盒蛋白纳米
SOX2
KLF4公司
诱导多能干细胞
重编程
生物
癌症研究
癌变
干细胞
癌症干细胞
细胞分化
细胞
癌症
细胞生物学
胚胎干细胞
基因
遗传学
作者
Daisuke Takeda,Takumi Hasegawa,Takeshi Ueha,Eiji Iwata,Risa Harada,Akiko Sakakibara,Teruya Kawamoto,Tsutomu Minamikawa,Yoshitada Sakai,Takahide Komori
出处
期刊:Anticancer Research
[Anticancer Research USA Inc.]
日期:2017-03-17
卷期号:37 (3): 1075-1082
被引量:9
标识
DOI:10.21873/anticanres.11419
摘要
Background/Aim: Cancer stem cells are suspected to contribute to malignancy in tumors. Hypoxia affects cell differentiation and induces stem-cell-like characteristics in malignancies. Induced pluripotency was demonstrated in mouse fibroblasts by reprogramming with four transcriptional factors: Oct3/4, Sox2, c-Myc, and Klf4. Conversely, oncogenic transformations frequently express transcriptional factors and Nanog. Therefore, cancer cells present some similarities with induced pluripotent stem (iPS) cells. Materials and Methods: We investigated the expression of iPS-related genes in vitro and in clinical samples to identify their relationships with hypoxia and tumorigenesis. Results: Oral squamous cell carcinoma (SCC) cells were used to show that expression levels of Oct3/4, Sox2, and Nanog were significantly increased in hypoxic condition in vitro and in moderately- and poorly-differentiated samples. Conclusion: We propose that Oct3/4, Sox2 and Nanog are associated with tumor hypoxia characterized in oral SCC and that these factors may also contribute to the undifferentiated potency observed in oral SCC clinically.
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