基质金属蛋白酶
血管生成
细胞外基质
伤口愈合
细胞生物学
生物
功能(生物学)
癌症研究
免疫学
生物化学
作者
Robert Visse,Hideaki Nagase
出处
期刊:Circulation Research
[Ovid Technologies (Wolters Kluwer)]
日期:2003-05-02
卷期号:92 (8): 827-839
被引量:4140
标识
DOI:10.1161/01.res.0000070112.80711.3d
摘要
Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These proteinases play a central role in many biological processes, such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration. Currently 23 MMP genes have been identified in humans, and most are multidomain proteins. This review describes the members of the matrixin family and discusses substrate specificity, domain structure and function, the activation of proMMPs, the regulation of matrixin activity by tissue inhibitors of metalloproteinases, and their pathophysiological implication.
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