Drug interactions of azole antifungals

Drug interactions can occur when two or more medications are simultaneously given, and one drug increases or decreases the effectiveness of the other. Azole antifungal agents show a wide range of interactions with other drugs. Failure to recognize a drug–drug interaction may produce harm to the patient, including enhanced toxicity of the concomitantly administered medication. Most of the interactions of azole antifungals are of pharmacokinetic type. This article reviews the clinically relevant drug interactions of commonly used antifungals - fluconazole and itraconazole.