免疫系统
脂肪组织
脂肪肝
生物标志物
接收机工作特性
酒精性肝病
免疫组织化学
渗透(HVAC)
基因
疾病
癌症研究
生物
内科学
医学
免疫学
物理
热力学
肝硬化
生物化学
作者
Yancheng Song,Jan Zhang,Hexiang Wang,Dong Guo,Chentong Yuan,Bo Liu,Hao Zhong,Dongmei Li,Yu Li
出处
期刊:Adipocyte
[Informa]
日期:2021-01-01
卷期号:10 (1): 424-434
被引量:17
标识
DOI:10.1080/21623945.2021.1970341
摘要
Increasing evidence shows that immune-related genes (IRGs) play an important role in bariatric surgery (BS). We identified differentially expressed immune-related genes (DEIRGs) of adipose tissue after BS by analysing the two expression profiles of GEO (GSE59034 and GSE29409). Subsequently, enrichment analysis, GSEA and PPI networks were examined to identify the hub IRGs and related pathways. The performance of the signature was evaluated by area under the curve (AUC) of the receiver operating characteristic (ROC). CIBERSORT algorithm was used to evaluate the relative abundance of infiltrated immune cells.42 DEIRGs were found between the GSE59034 and GSE29409 datasets. The AUC of the signature was 0.904 and 0.865 in the GSE58979 and GSE48452, respectively. Interestingly, the signature also showed good performance in diagnosing non-alcoholic fatty liver disease (NAFLD) (AUC was 0.834 and 0.800, respectively). The number of neutrophils, macrophages M2, macrophages M0 and dendritic cells activated decreased significantly. After BS, the infiltration of T cells regulatory, monocytes, mast cells resting and plasma cells in adipose tissue increased. The novel proposed IRGs signature reveals the underlying immune mechanism of BS and is a promising biomarker for distinguishing the severity of NAFLD. This will provide new insights into strategies for treating obesity and NAFLD.
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