Nepal, similar to other countries, has faced different types of natural disasters. In fact, Nepal has experienced more natural disasters than any other South Asian country. According to trends analysis, every year, different types of natural disasters have occurred in Nepal, for example landslides, floods, and earthquakes are major natural disasters. The occurrences and effects of natural disasters in various parts of the world have highlighted the importance to intensify mutual cooperation among the disaster management stakeholders in order to reduce the impact of potential disasters. Therefore, the aim of this paper is to describe the role of government and non-governmental organizations (NGOs) that are involved in managing disasters in Nepal. Both the Government and NGOs should adopt preventive measures in due time to reduce the impact of disasters. To achieve this government and the NGOs should work in close cooperation and coordination. For an effective disaster mitigation, early warning system, insurance system, emergency rescue and relief operation, rehabilitation and recovery plans should be in place. Activities such as training, post-disaster evaluation, monitoring of relief works, review, cooperation and coordination of central, district and local level preparedness, rehabilitation, reconstruction and research works must be considered.