Synthesis of Thymidine Dimers from 5′-O-Aminothymidine

The synthesis of modified oligonucleotides is of great importance for various therapeutic and diagnostic applications. The facile secondary structure formation of N -oxyamide-linked peptide analogues and the high nucleophilicity of the aminooxy function prompted us to prepare O -amino nucleoside derived dinucleosides. Herein, the efficient synthesis of three novel thymidine dimers with N -oxyamide, oxime and oxyamine linkages via a convergent approach from a common 5′- O -aminothymidine is reported.