Distribution of intestine T lymphocytes before and after rheumatoid arthritis

Objective To discuss the variation of intraepithelial lymphocyte and lamina propria lymphocyte of small intestine(duodenum,jejunum,ileum) in rat under the condition in the patients with rheumatoid arthritis.Methods By immunohistochemical staining method,we observed the normal group and disease-causing group intestine mucosa variation of Tlymphocyte,calculated the quantity of IEL and LPL,and analyzed the result statistically.Results The amount of IEL and LPL in various part(duodenum,jejunum,ileum) of rat increased under the pathogenic group.Conclusion By immunohistochemical method that under the conditions of patients with rheumatoid arthritis,intestinal mucosa epithelium and lamina propria could be seen an increase in the distribution of T lymphocytes.IEL and LPL in different part of the intestine tract may play important biological roles in immune response of mucosa.