Preparation and Application of Polyvinyl Alcohol-Magnetic Drug Carrier Modified by Sorbitan Monooleate-Polyethylene Glycol

A new non-ionic surfactant was synthesized by using Span 80 and polyethylene glycol 400(PEG 400) in the presence of succinic anhydride. Then, the surfactant was grafted onto PVA-coated Fe3O4 magnetic nanoparticles. As a result, a kind of new drug carrier with magnetic targeting was prepared. Several instruments, such as FTIR, NMR, XRD, TEM were used to characterized the carrier. Finally, the targeting carrier was applied to envelop the amphotericin. The envelopment was up to 96.6%, and the method was handy.