Differentiation inducing effect of arsenic trioxide on the C_6 glioma cells

Objective To evaluate the differentiation inducing effect of arsenic trioxide on the C_6 glioma cells.Methods The expression of GFAP and C-myc protein of the C_6glioma cells were observed with SP immunohistochemistry,which were induced by arsenic trioxide in different time and different concentration.Results The expression of GFAP of the glioma was significantly increased by low concentration arsenic trioxide(0.5～2.0 μmol/L),and a significant decrease of C-myc protein was demonstrated(P0.05).Conclusion The differentiation of C_6glioma cells could be induced by arsenic trioxide effectively.The malignant degree of glioma is decreased after induced by arsenic trioxide.