Risk Prediction of High Sensitivity C-reactive Protein Level for Ischemic Stroke Events

Objective To study the risk prediction of high sensitivity C-reactive protein level for ischemic stroke(IS) events.Methods In a retrospective,nested,case-control study,842 cases of IS were identified and matched with 1684 controls.The hsCRP levels at baseline were compared between these two groups.Relation of different hsCRP levels and the risk of IS events were analyzed.Results The baseline levels of hsCRP in IS cases were higher than that in control group(Median 1.63 vs 0.79 mg/L).In addition,it was found that the individuals with the highest quartile hsCRP levels have an increased risk of IS(OR=3.73,95% CI 2.87-4.86) as compared with those in the lowest quartile.Individuals with hsCRP levels above the prespecified cut point of 3 mg/L or above the 80th percentile at basiline were at a markedly increased risk of IS(for prespecified cut point of 3 mg/L,OR=2.65,95% CI 2.16-3.25,P0.01;for 80th percentile,OR=2.85,95% CI 2.29-3.55,P0.01,respectively).Conclusions Risk of IS events might be predicted by the level of hsCRP.With the increasing of hsCRP level in baseline,the risk of IS was increased.