Ganoderma lucidum is famous for the medicinal fungi and new food resources, the main active substances and submerged fermentation technology of Ganoderma lucidum had already many systematic and in-depth studies at home and abroad. In this paper, Ganoderma lucidum main active substances Ganoderma polysaccharides, Ganoderma triterpenoids and Ganoderma submerged fermentation technology of the latest research results were reviewed.