慢性淋巴细胞白血病
肿瘤微环境
癌症研究
白血病
CXCR4型
生物
免疫学
细胞生物学
肿瘤细胞
炎症
趋化因子
作者
Roberta Valsecchi,Nadia Coltella,Daniela Belloni,Manfredi Ponente,Elisa ten Hacken,Cristina Scielzo,Lydia Scarfò,Maria Teresa Sabrina Bertilaccio,Paola Brambilla,Elisa Lenti,Filippo Martinelli Boneschi,Andrea Brendolan,Elisabetta Ferrero,Marina Ferrarini,Paolo Ghia,Giovanni Tonon,Maurilio Ponzoni,Federico Caligaris‐Cappio,Rosa Bernardi
出处
期刊:Blood
[Elsevier BV]
日期:2016-01-30
卷期号:127 (16): 1987-1997
被引量:55
标识
DOI:10.1182/blood-2015-07-657056
摘要
Key Points HIF-1α critically regulates the interaction of neoplastic CLL cells with the leukemic microenvironment. HIF-1α is regulated at the transcriptional level in CLL patients and correlates with CXCR4 expression.
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