Isolation and identification of the secondary metabolites from marine actinomycete KSC2-1

Objective To study the chemical constituents from marine actinomycete KSC2-1. Methods The compounds were isolated by silica gel column,Sephadex LH-20 column and HPLC,and their structures were identified by 1H-NMR,13C-NMR and comparison of chemical and physical data with authentic samples reported in literatures. Results Ten compounds were isolated from the n-butanol extracts of marine actinomycete KSC2-1.They were identified as:3-(α-hydroxypropionyl)-1H-indole( 1),3-acetyl-1H-indole( 2),1H-indole-3-carbaldehyde( 3),1H-indole-3-carboxylic acid( 4),2-(1H-indol-3-y1)ethanol( 5),3-ethyl-3-hydroxy-1-methylindolin-2-one( 6),2-hydroxy-1-(4-hydroxyphenyl)ethanone( 7),4-(2-hydroxyethyl)phenol( 8),thymine nucleoside deoxyribose( 9),uracil nucleoside( 10). Conclusions All of the compounds are obtained from marine actinomycete KSC2-1 for the first time.