Therapeutic efficacy of hepatic arterial infusion chemotherapy based on oxaliplatin for colorectal cancer liver metastases

AIM: To evaluate the efficacy of hepatic arterial infusion chemotherapy (HAIC) based on oxaliplatin for treatment of the patients with multiple liver metastases from colorectal cancer. METHODS: Twenty-six patients (treatment group) with multiple liver metastases from colorectal cancer were treated 58 times by HAIC and embolotherapy, and chemotherapeutic agents used were oxaliplatin 130 mg/m2, leucovorin 200 mg/m2, 5-fluorouracil 750 mg/m2. Meanwhile, 20 patients (control group) were treated with modified FOLFOX4 regimen. Preliminary efficacy, change of body state and post-chemotherapy toxic reaction were observed and compared between the 2 groups. RESULTS: Preliminary efficacy of treatment group was prior to that of control group obviously (57.7% vs 40.0%,P0.05); Karmofsky scores were raised after treatment in treatment group (P0.05), while they were degraded in control group (P0.05); side effects of treatment group were lighter than those of control group, such as nausea and vomiting (P0.05). CONCLUSION: Compared with FOLFOX4 regimen, HAIC based on oxaliplatin can enhance preliminary therapeutic efficacy.