三醋酸纤维素
纤维素
超滤(肾)
膜
纳米材料
透析
材料科学
透析管
纤维
化学工程
化学
色谱法
纳米技术
有机化学
复合材料
生物化学
外科
医学
工程类
作者
John P. Moore,Kristyn Robling,Cristian Romero,Keturah Kiper,Soma Shekar Dachavaram,Peter A. Crooks,Jamie A. Hestekin
出处
期刊:Polymers
[MDPI AG]
日期:2020-06-15
卷期号:12 (6): 1348-1348
被引量:2
标识
DOI:10.3390/polym12061348
摘要
Recent exploration of cellulose nanomaterials has resulted in the creation of Oxone®-Mediated TEMPO-Oxidized Cellulose Nanomaterials (OTO-CNMs). These materials, when incorporated into a polymer matrix, have properties showing increased flux, decreased membrane resistance, and improved clearance, making them an ideal material for dialysis. This study is the first to focus on the implementation of OTO-CNMs into hollow fiber membranes and a comparison of these membranes for ultrafiltration and dialysis. Ultrafiltration and dialysis were performed using bovine serum albumin (BSA), lysozyme, and urea to analyze various properties of each hollow fiber membrane type. The results presented in this study provide the first quantitative evaluation of the clearance and sieving characteristics of Oxone®-Mediated TEMPO-Oxidized Cellulose-Nanomaterial-doped cellulose triacetate mixed-matrix hemodialyzers. While the cellulose nanomaterials increased flux (10-30%) in ultrafiltration mode, this was offset by increased removal of albumin. However, in dialysis mode, these materials drastically increased the mass transfer of components (50-100%), which could lead to significantly lower dialysis times for patients. This change in the performance between the two different modes is most likely due to the increased porosity of the cellulose nanomaterials.
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