Evaluation of Primary Liver Cancers Using Hepatocyte‐Specific Contrast‐Enhanced MRI: Pitfalls and Potential Tips

When radiologists interpret hepatic focal lesions seen on dynamic magnetic resonance imaging (MRI) scans, it is important not only to distinguish malignant lesions from benign ones but also to distinguish nonhepatocellular carcinoma (HCC) malignancies from HCCs. In addition, most major guidelines, including those of the American Association for the Study of Liver Disease, European Association for the Study of the Liver, and Korean Liver Cancer Association and National Cancer Center, allow for the noninvasive imaging diagnosis of HCC in at‐risk patients. However, ~40% of HCC cases show atypical imaging features mimicking non‐HCC malignancies. Furthermore, several benign and malignant lesions, such as flash‐filling hemangioma and intrahepatic mass‐forming cholangiocarcinoma, frequently look like HCC. In contrast, although multiparametric MRI options, including hepatobiliary phase and diffusion‐weighted imaging, provide useful information that could help address these challenges, there remain several unresolved issues with regard to the noninvasive diagnostic criteria characterizing HCC. In this article, we discuss the typical imaging features and challenging situations related to primary liver cancers in MRI, while considering how to make a correct diagnosis. Level of Evidence 5 Technical Efficacy Stage 3