卟啉
光动力疗法
钆
体内
光敏剂
癌症研究
顺铂
化学
衍生工具(金融)
磁共振成像
医学
光化学
化疗
内科学
放射科
生物
有机化学
经济
生物技术
金融经济学
作者
Bo Wu,Xiaoqi Li,T. C. Huang,Shiqiang Lu,Bing Wan,Rufang Liao,Yushuang Li,Aju Baidya,Qingyun Long,Haibo Xu
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2017-01-01
卷期号:5 (9): 1746-1750
被引量:26
摘要
Porphyrin derivatives have been widely applied in MR imaging and photodynamic cancer therapy. We here report a novel Gd/Pt bifunctionalized porphyrin derivative (Gd/Pt-P1) for MRI-guided chemo-photodynamic cancer therapy. Gd/Pt-P1 was prepared from tetra(4-pyridyl) porphyrin (P1) via step by step coordination to cisplatin and gadolinium (Gd(iii)). Gd/Pt-P1 showed a particularly high synergetic chemo-photodynamic antitumor effect in vivo with a tumor inhibition rate (TIR) of 96.6% and excellent MR imaging performance.
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