免疫疗法
肿瘤微环境
免疫系统
癌症免疫疗法
黑色素瘤
体内
癌症研究
临床前影像学
癌症
医学
材料科学
纳米技术
免疫学
生物
内科学
生物技术
作者
Swati Kataria,Jifa Qi,Ching‐Wei Lin,Zhong‐Ming Li,Eric L. Dane,Archana Mahadevan Iyer,Jay Sacane,Darrell J. Irvine,Angela M. Belcher
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-09-07
卷期号:17 (18): 17908-17919
被引量:1
标识
DOI:10.1021/acsnano.3c03882
摘要
Only a minority of patients respond positively to cancer immunotherapy, and addressing this variability is an active area of immunotherapy research. Infiltration of tumors by immune cells is one of the most significant prognostic indicators of response and disease-free survival. However, the ability to noninvasively sample the tumor microenvironment for immune cells remains limited. Imaging in the near-infrared-II region using rare-earth nanocrystals is emerging as a powerful imaging tool for high-resolution deep-tissue imaging. In this paper, we demonstrate that these nanoparticles can be used for noninvasive in vivo imaging of tumor-infiltrating T-cells in a highly aggressive melanoma tumor model. We present nanoparticle synthesis and surface modification strategies for the generation of small, ultrabright, and biocompatible rare-earth nanocrystals necessary for deep tissue imaging of rare cell types. The ability to noninvasively monitor the immune contexture of a tumor during immunotherapy could lead to early identification of nonresponding patients in real time, leading to earlier interventions and better outcomes.
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