This chapter discusses the process and content of a histopathology report, including the supplementary report. As well as containing all the patient demographical information, the report is divided into specific sections. A histopathology report is a verified document that contains a diagnosis, which is determined following the examination of cells, tissues, and sometimes foreign or infectious agents under the microscope. The chapter then looks at the key microscopic observations seen in the two key areas of histopathology – inflammation and cancer. It highlights the use of diagnostic datasets and the role of tissue pathways in histopathology, as well as the value of molecular/genetic information in histopathology reports.