Whether jugular venous reflux relates to more serious ischemic white matter lesions?

To evaluate whether jugular venous reflux (JVR) relates to more serious ischemic white matter lesions (WMLs).Fifty cases were enrolled and divided into absent to mild ischemic WMLs group and moderate to severe ischemic WMLs group. Then the univariate and multivariate analyses were conducted to evaluate the relationship between JVR and moderate to severe ischemic WMLs, and a receiver operating characteristic (ROC) curve was used to evaluate the predictive value of JVR for moderate to severe ischemic WMLs.There were 28 patients in the absent to mild ischemic WMLs group and 22 patients in the moderate to severe ischemic WMLs group. There was no significant difference between the two groups in gender, blood lipid indexes, proportions of diabetes, and abnormal deep cerebral veins (all p > 0.05). However, compared with the absent to mild ischemic WMLs group, the moderate to severe ischemic WMLs group was older and had a higher proportion of hypertension and JVR (p = 0.005; p < 0.001; p < 0.001, respectively). Multivariate logistic regression analysis showed that JVR was an independent risk factor for moderate to severe ischemic WMLs (OR = 17.679, 95 % CI: 3.056-102.286, p = 0.001). Furthermore, the area under curve of JVR combined with hypertension was 0.912 (p < 0.001), and the specificity of predicting moderate to severe ischemic WMLs was 92.9 %.Our study suggested that JVR might relate to more severe ischemic WMLs.