认知
认知功能衰退
痴呆
心理学
神经心理学
认知老化
风险因素
老年学
神经心理评估
睡眠剥夺对认知功能的影响
情景记忆
临床心理学
发展心理学
医学
精神科
内科学
疾病
作者
Hannah L Shields,Kyoko Konishi,Sarah A. Aroner,Harlyn Aizley,Anne Remington,Hang Lee,Stephen L. Buka,Jill M. Goldstein
摘要
Abstract The current study aimed to understand how sex differences in the timing of hypertension onset contribute to early midlife risk for cognitive decline that may differ by sex and whether sex‐dependent advantages in normotensive populations are influenced by the presence of hypertension. One hundred and ninety‐five adults aged 45–55 from the New England Family Study underwent neuropsychological testing to assess attention, executive function, and memory. Physician‐diagnosed hypertension status was self‐reported via questionnaire. Mid‐adulthood hypertension was associated with worse performance on measures of attention and memory, but the cognitive domains impacted varied by sex. Hypertension was associated with only attention in men, whereas in women it was associated with attention and associative and working memory. Sex differences in midlife cognitive performance found in normotensive adults were attenuated in those with hypertension. Our results underscore the importance of accounting for sex when assessing the impact of hypertension on midlife cognition that could be indicative of later decline and risk for cognitive impairment and dementia, given hypertension is an independent risk factor.
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