可执行文件
化学
寡核苷酸
计算机科学
嵌入式系统
程序设计语言
DNA
生物化学
作者
J. Sebastián Manzano,Wenduan Hou,Sergey S. Zalesskiy,Przemysław Frei,Hsin Wang,Philip J. Kitson,Leroy Cronin
出处
期刊:Nature Chemistry
[Springer Nature]
日期:2022-10-06
卷期号:14 (11): 1311-1318
被引量:14
标识
DOI:10.1038/s41557-022-01016-w
摘要
Robotic systems for synthetic chemistry are becoming more common, but they are expensive, fixed to a narrow set of reactions, and must be used within a complex laboratory environment. A portable system that could synthesize known molecules anywhere, on demand, and in a fully automated way, could revolutionize access to important molecules. Here we present a portable suitcase-sized chemical synthesis platform containing all the modules required for synthesis and purification. The system uses a chemical programming language coupled to a digital reactor generator to produce reactors and executable protocols based on text-based literature syntheses. Simultaneously, the platform generates a reaction pressure fingerprint, used to monitor processes within the reactors and remotely perform a protocol quality control. We demonstrate the system by synthesizing five small organic molecules, four oligopeptides and four oligonucleotides, in good yields and purities, with a total of 24,936 base steps executed over 329 h of platform runtime. Automated systems, nowadays more commonly used in laboratory settings, are typically fixed to a narrow set of reactions and used within a complex laboratory environment. Now, a portable platform has been developed for the on-demand and on-site multistep synthesis of organic molecules, oligonucleotides and oligopeptides mapped into reactionware systems.
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