MRI dynamic changes and mechanism of glymphatic system of hypertensive cerebral edema

Motivation: The pathogenesis of hypertensive cerebral edema remains elusiveGoal(s): To visualize and evaluate the transport function of the glymphatic system in the spontaneously hypertensive rats (SHR). Approach: We used the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and immunofluorescence analysisResults: And we found that there was a significant change in the transport function of the glymphatic system and a decrease in the expression of aquaporin-4 (AQP4) around blood vessels. Impact: The combination of DCE-MRI and immunofluorescenc analysis can facilitate further exploration of mechanisms underlying brain edema in the spontaneously hypertensive animal models, thus aiding in the study of the glymphatic system.