医学
脑血流
白质
心脏病学
高强度
内科学
磁共振成像
放射科
作者
Yao Zhang,Ruiting Zhang,Hui Hong,Shuyue Wang,Linyun Xie,Lei Cui,Jixuan Li,Luwei Hong,Kaicheng Li,Qingze Zeng,Ying Zhou,Minming Zhang,Jianyong Sun,Peiyu Huang
摘要
Background Vascular degeneration is an important cause of brain damage in aging. Assessing the functional properties of the cerebral vascular system may aid early diagnosis and prevention. Purpose To investigate the relationships between potential vascular functional markers and vascular risks, brain parenchymal damage, and cognition. Study Type Retrospective. Subjects Two hundred two general community subjects (42–80 years, males/females: 127/75). Field Strength/Sequence 3 T, spin echo T1W/T2W/FLAIR, resting‐state functional MRI with an echo‐planar sequence (rsfMRI), pseudo‐continuous arterial spin labeling (pCASL) with a three‐dimensional gradient‐spin echo sequence. Assessment Cerebral blood flow (CBF) in gray matter calculated using pCASL, blood transit times calculated using rsfMRI, and the SD of internal carotid arteries signal (ICA std ) calculated using rsfMRI; visual assessment for lacunes; quantification of white matter hyperintensity volume; permutation test for quality control; collection of demographic and clinical data, Montreal Cognitive Assessment, Mini‐Mental State Examination. Statistical Tests Kolmogorov–Smirnov test; Spearman rank correlation analysis; Multivariable linear regression analysis controlling for covariates; The level of statistical significance was set at P < 0.05. Results Age was negatively associated with ICA std ( β = −0.180). Diabetes was associated with longer blood transit time from large arteries to capillary bed ( β = 0.185, adjusted for age, sex, and intracranial volume). Larger ICA std was associated with less presence of lacunes (odds ratio: 0.418, adjusted for age and sex). Higher gray matter CBF ( β = 0.154) and larger ICA std ( β = 0.136) were associated with better MoCA scores (adjusted for age, sex, and education). Data Conclusion Prolonged blood transit time, decreased ICA std , and diminished CBF were associated with vascular dysfunction and cognitive impairment. They may serve as vascular functional markers in future studies. Evidence Level 3 Technical Efficacy Stage 3
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