小RNA
柴油机排气
签名(拓扑)
肝损伤
医学
柴油
化学
内科学
汽车工程
基因
工程类
生物化学
几何学
数学
作者
Lin Xu,Yanting Li,Wanli Ma,Xueying Sun,Rongrong Fan,Jing Yuan,Ningning Chen,Xiaoxiao Zhu,Huan Guo,Kunming Zhao,Jiao Luo,Chuanhai Li,Yuxin Zheng,Dianke Yu
标识
DOI:10.1016/j.jhazmat.2023.132060
摘要
Diesel exhaust particles (DEP) pollution should be taken seriously because it is an extensive environmental and occupational health concern. Exploring early effect biomarkers is crucial for monitoring and managing DEP-associated health risk assessment. Here, we found that serum levels of 67 miRNAs were dysregulated in DEP exposure group. Notably, 20 miRNAs were identified as each having a significant dose-response relationship with the internal exposure level of DEP. Further, we revealed that the DEP exposure could affect the liver function of subjects and that 7 miRNAs (including the well-known liver injury indicator, miR-122-5p) could serve as the novel epigenetic-biomarkers (epi-biomarkers) to reflect the liver-specific response to the DEP exposure. Importantly, an unprecedented prediction model using these 7 miRNAs was established for the assessment of DEP-induced liver injury risk. Finally, bioinformatic analysis indicated that the unique set of miRNA panel in serum might also contribute to the molecular mechanism of DEP exposure-induced liver damage. These results broaden our understanding of the adverse health outcomes of DEP exposure. Noteworthy, we believe this study could shed light on roles and functions of epigenetic biomarkers from environmental exposure to health outcomes by revealing the full chain of exposure-miRNAs-molecular pathways-disease evidence.
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