Versatile Hypoxic Extracellular Vesicles Laden in an Injectable and Bioactive Hydrogel for Accelerated Bone Regeneration (Adv. Funct. Mater. 21/2023)

Extracellular Vesicles In article number 2211664, Yuehua Liu, Lin Yu, Liming Yu, and co-workers, design a hypoxic treatment strategy to increase extracellular vesicles (EVs) production and boost their therapeutic efficacy. An injectable bioactive hydrogel is developed to improve the in vivo stability and retention of EVs, thereby synergistically accelerating bone regeneration. This simple but effective strategy is expected to become a paradigm for cell-free therapies.