化学
烷基
钯
烷基化
催化作用
废止
反应性(心理学)
激进的
激发态
氯化物
有机化学
光化学
组合化学
核物理学
病理
替代医学
物理
医学
作者
Krishnamoorthy Muralirajan,Rajesh Kancherla,Aidana Gimnkhan,Magnus Rueping
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-08-25
卷期号:23 (17): 6905-6910
被引量:39
标识
DOI:10.1021/acs.orglett.1c02467
摘要
Excited-state palladium catalysis is an efficient process for the alkylation of diverse organic compounds via the generation of alkyl radicals from alkyl bromides and iodides. However, the generation of alkyl radicals from more stable alkyl chlorides remains challenging. Herein, we demonstrate the excited-state palladium-catalyzed synthesis of oxindoles and isoquinolinediones via alkylation/annulation reaction by overcoming inherent limitations associated with unactivated C(sp3)–Cl bond activation at room temperature.
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