Impact of Ozone gel, PRF & A-PRF on Pain and Trismus during Tissue Healing after Extraction of Mandibular Third Molars

Objective: This prospective study evaluated the impact of ozone gel, conventional PRF (C-PRF) and advanced PRF (A-PRF) on pain and trismus when applied after surgical extraction of impacted mandibular third molars. Materials and Methods: This study included 48 patients with impacted mandibular third molars. They were randomly divided into 4 groups, group I (control); didn't receive any material in the socket, group II: sockets received ozone gel, group III: sockets received PRF while in group IV: sockets received A-PRF. Pain assessment using VAS, analgesics consumption, and maximum mouth opening were evaluated on day 1, day 3 and day 7 follow-up. Results: Less values of VAS pain scores were recorded in group II in comparison with the control group on day 1, day 3 and day 7 with a statistically significant difference of (P=0.018), (P=0.044) and (P=0.015) respectively. The analgesics consumption showed a statistically significant difference in group II compared to group I (P=0.020) and (P=0.021) on day 1 and day 3 respectively, but day 7 was statistically insignificant (P=0.165). Maximum mouth opening was statistically significant (P=0.042) on day3 in group II when compared with group I. Conclusion: The present study shows that ozone gel can be of paramount importance in minimizing post-operative symptoms as regard to pain and trismus following the extraction of impacted mandibular third molars and appears to improve patient's relief and quality of life after surgery.