对映体药物
溶剂
对映体
化学
选择性
手性(物理)
金属有机骨架
溶剂效应
洗脱
手性柱色谱法
对映选择合成
相(物质)
吸附
有机化学
色谱法
催化作用
手征对称破缺
量子力学
Nambu–Jona Lasinio模型
物理
夸克
作者
Benjamin Slater,Matthew R. Hill,Bradley P. Ladewig
标识
DOI:10.1002/jssc.202100322
摘要
Abstract Solvent‐induced enantioselectivity reversal is a rarely reported phenomenon in porous homochiral materials. Similar behavior has been studied in chiral high performance liquid chromatography, where minor modifications to the mobile phase can induce elution order reversal of two enantiomers on a chiral stationary phase column. We report the first instance of solvent‐induced enantioselectivity reversal in a homochiral metal organic framework. Further, we highlight the complex enantioselectivity behavior of homochiral metal organic frameworks toward racemic mixtures in the presence of solvents through racemate‐solvent enantioselectivity and loading experiments as well as enantiopure‐solvent loading experiments. We hypothesize that this interesting selectivity reversal behavior is likely to be observed in other competitive adsorption, nonchiral selective processes involving a solvent.
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