孤独
遗传力
遗传学
行为遗传学
表观遗传学
特质
心理学
现存分类群
遗传力缺失问题
基因
进化生物学
生物
社会心理学
遗传变异
计算机科学
基因型
程序设计语言
作者
Luc Goossens,Eeske van Roekel,Maaike Verhagen,John T. Cacioppo,Stephanie Cacioppo,Marlies Maes,Dorret I. Boomsma
标识
DOI:10.1177/1745691614564878
摘要
As a complex trait, loneliness is likely to be influenced by the interplay of numerous genetic and environmental factors. Studies in behavioral genetics indicate that loneliness has a sizable degree of heritability. Candidate-gene and gene-expression studies have pointed to several genes related to neurotransmitters and the immune system. The notion that these genes are related to loneliness is compatible with the basic tenets of the evolutionary theory of loneliness. Research on gene-environment interactions indicates that social-environmental factors (e.g., low social support) may have a more pronounced effect and lead to higher levels of loneliness if individuals carry the sensitive variant of these candidate genes. Currently, there is no extant research on loneliness based on genome-wide association studies, gene-environment-interaction studies, or studies in epigenetics. Such studies would allow researchers to identify networks of genes that contribute to loneliness. The contribution of genetics to loneliness research will become stronger when genome-wide genetics and epigenetics are integrated and used along with well-established methods in psychology to analyze the complex process of gene-environment interplay.
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