巩膜
表观遗传学
医学
生物
基因敲除
细胞生物学
染色质
泛素
眼睛发育
机制（生物学）
泛素连接酶
组蛋白
遗传学
人类遗传学
脉络膜新生血管
脱甲基酶
眼科
黄斑变性
豚鼠
染色质重塑
作者
Yi Lei,Xiaolei Lin,Xuemei Ling,Yuhan Tan,Jian Yuan,Yating Li,Mengqi Di,Yulu Pan,Lurong Zhong,Zhaoning Feng,Fangfang Jiao,Changxi Hu,Hanyu Deng,Miaozhen Pan,Jianzhong Su,Jia Qu,W C Chen,Fei Zhao,X Y Zhou
标识
DOI：10.1186/s13073-026-01652-8
摘要
Our findings suggested that scleral H3K27me3 is an epigenetic mediator that connects intermittent myopiagenic exposures to persistent chromatin remodeling and myopia progression. The data support a model involving the " KDM6A-H3K27me3-Sp1" axis, providing a molecular framework for understanding the cumulative biological effects of myopiagenic risk factors.
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(2025-6-4)
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