Photoinduced C3 - Alkylation of Pyridines with Unactivated Alkyl Halides

Abstract Herein, we disclose a photoinduced Pd-catalyzed protocol that enables a meta-alkylation of pyridines via dearomatized oxazine intermediates with unactivated alkyl halides as coupling partners. This method offers a practical gateway to rapidly and reliably incorporate primary, secondary, or even tertiary alkyl fragments at the C3 position of the pyridine core, including site-selective diversification of advanced azine derivatives.