The goal of plant genetic engineering is to obtain transgenic plants that foreign gene can be normally expressed and faithfully inheritted in a predictable manner. But in recent years,it was widely reported that transgene silencing was often found in transgene plant. In this article,we discuss two level of transgene silencing phenomenon: Transcriptional Gene silencing and Posttranscriptional Gene silencing. Its mechanisms involved DNADNA,DNARNA,RNARNA,interaction respectively,and we discuss some strategies to overcome transgene silencing also. Especially,Matrix attachment region(MAR)show capacity to increase level of transgene expression and reduce transformattotransformat variation of transgene expression in stable transformated plant.