化学
吲哚试验
电化学
化学空间
化学合成
全合成
组合化学
氧化磷酸化
立体化学
有机化学
药物发现
生物化学
体外
电极
物理化学
作者
Brandon R. Rosen,Erik W. Werner,Alexander G. O’Brien,Phil S. Baran
摘要
N–N-linked dimeric indole alkaloids represent an unexplored class of natural products for which chemical synthesis has no practical solution. To meet this challenge, an electrochemical oxidative dimerization method was developed, which was applied as the pivotal step of the first total synthesis of dixiamycin B. This method is also general for N–N dimerization of substituted carbazoles and β-carbolines, providing entry into seldom explored chemical space.
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