生物
胶质瘤
小桶
热休克蛋白
亚细胞定位
基因
计算生物学
细胞生物学
基因表达
热冲击
遗传学
转录组
作者
Huizhen Sun,Hai-Ying Zou,Xinyi Cai,Huicheng Zhou,Xiaoqi Li,Weijie Xie,Wenming Xie,Zhifeng Du,Li‐Yan Xu,En‐Min Li,Bingli Wu
标识
DOI:10.1089/dna.2020.5425
摘要
Heat shock protein (HSP) is a family of highly conserved protein, which exists widely in various organisms and has a variety of important physiological functions. Currently, there is no systematic analysis of HSPs in human glioma. The aim of this study was to investigate the characteristics of HSPs through constructing protein–protein interaction network (PPIN) considering the expression level of HSPs in glioma. After the identification of the differentially expressed HSPs in glioma tissues, a specific PPIN was constructed and found that there were many interactions between the differentially expressed HSPs in glioma. Subcellular localization analysis shows that HSPs and their interacting proteins distribute from the cell membrane to the nucleus in a multilayer structure. By functional enrichment analysis, gene ontology analysis, and Kyoto Encyclopedia of Genes and Genomes pathway analysis, the potential function of HSPs and two meaningful enrichment pathways was revealed. In addition, nine HSPs (DNAJA4, DNAJC6, DNAJC12, HSPA6, HSP90B1, DNAJB1, DNAJB6, DNAJC10, and SERPINH1) are prognostic markers for human brain glioma. These analyses provide a full view of HSPs about their expression, biological process, as well as clinical significance in glioma.
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