[Progress in study on animal models of 
chronic obstructive pulmonary disease].

Chronic obstructive pulmonary disease (COPD) is an incompletely reversible chronic airway disease that can be prevented and cured. There is a tendency toward increasing the morbidity and mortality for COPD. Establishment of an animal model for COPD is an important step to explore the pathogenesis of this disease. Presently, a well-recognized COPD animal model is not available. The key points for establishing the COPD animal models, such as selection of animal species, parameters for model evaluation, are constantly updated.慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)是一种可以预防和治疗的不完全可逆性慢性气道疾病，其发病率和致死率均较高，并且呈逐年上升趋势。建立COPD动物模型是探索其发病机制的重要方法之一，目前缺乏统一标准的COPD动物模型构建方法，动物物种选择、模型制备及模型评估作为该模型构建的关键点在不断更新。.