医学
败血症
重症监护医学
梅德林
数据提取
协议(科学)
人口
器官功能障碍
临床试验
儿科
内科学
替代医学
病理
政治学
环境卫生
法学
作者
Kusum Menon,Luregn J Schlapbach,Samuel Akech,Andrew C. Argent,Kathleen Chiotos,Mohammod Jobayer Chisti,Jemila S Hamid,Paul Ishimine,Niranjan Kissoon,Rakesh Lodha,Cláudio Flauzino de Oliveira,Mark Peters,Pierre Tissières,R. Scott Watson,Matthew O. Wiens,James L. Wynn,Lauren R. Sorce
标识
DOI:10.1097/cce.0000000000000123
摘要
Sepsis is responsible for a substantial proportion of global childhood morbidity and mortality. However, evidence demonstrates major inaccuracies in the use of the term "sepsis" in clinical practice, coding, and research. Current and previous definitions of sepsis have been developed using expert consensus but the specific criteria used to identify children with sepsis have not been rigorously evaluated. Therefore, as part of the Society of Critical Care Medicine's Pediatric Sepsis Definition Taskforce, we will conduct a systematic review to synthesize evidence on individual factors, clinical criteria, or illness severity scores that may be used to identify children with infection who have or are at high risk of developing sepsis-associated organ dysfunction and separately those factors, criteria, and scores that may be used to identify children with sepsis who are at high risk of progressing to multiple organ dysfunction or death.We will identify eligible studies by searching the following databases: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials.We will include all randomized trials and cohort studies published between January 1, 2004, and March 16, 2020.Data extraction will include information related to study characteristics, population characteristics, clinical criteria, and outcomes.We will calculate sensitivity and specificity of each criterion for predicting sepsis and conduct a meta-analysis if the data allow. We will also provide pooled estimates of overall hospital mortality.The potential risk factors, clinical criteria, and illness severity scores from this review which identify patients with infection who are at high risk of developing sepsis-associated organ dysfunction and/or progressing to multiple organ dysfunction or death will be used to inform the next steps of the Pediatric Sepsis Definition Taskforce.
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