Hypoxia-inducible factor 1 and endometrial carcinoma

Hypoxia-inducible factor 1 ( HIF-1 ) can receive and conduct signals under hypoxia,so it participates in the transcriptions of some genes induced by hypoxia.Hypoxia can cause an increasing expression of HIF-1 α in endomettial carcinoma,which might work on angiogenesis,glycometabolism,invasion,prolifera-tion,apoptosis,differentiation and prognosis of tumor.HIF-1α attracts more and more attention in recent years,detection of HIF-1α in endometrial carcinoma may be useful for its therapy. Key words: Endometrial neoplasms; Anoxia; Hypoxia inducible factor-1