An Efficient Method for the Synthesis of a Novel Leukotriene B4 Receptor Antagonist, ONO-4057, via Michael Reaction of Dihydroresorcinol

All articles of this category A practical method for the synthesis of ONO-4057, a highly potent and orally active leukotriene B 4 (LTB 4 ) receptor antagonist, was developed. This method includes improved synthesis of a key intermediate, 1,3-dioxo-2-(2-ethoxycarbonylethyl)cyclohexane ( 6 ). leukotriene B4 - antagonist - dihydroresorcinol - Michael addition