自愈水凝胶
材料科学
壳聚糖
双层
聚合
化学工程
自由基聚合
丙烯酸
高分子化学
复合材料
聚合物
膜
化学
共聚物
生物化学
工程类
作者
Tamara Erceg,Gaja Brakus,Alena Stupar,Miroslav Cvetinov,Miroslav Hadnađev,Ivan Ristić
标识
DOI:10.1007/s10924-022-02473-7
摘要
The paper presents the synthesis of hydrogels via free-radical polymerization, based on Chitosan (CS) grafted with Acrylic acid (AA), using a two-step procedure. Free-radical polymerization has given strong hydrogels with compact structure, dominant elastic behavior, and long linear viscoelastic region. The results of rheological studies have shown that obtained hydrogels have significantly improved mechanical properties in comparison to chitosan hydrogels obtained by other sustainable methods. A step forward in the investigation of the potential application of chitosan hydrogels in wound dressing systems has been made by preparation of the bilayer design by embedding a layer of active compound-loaded alginate beads into the contact surface between two conjoined units of CS/AA hydrogels. Wild garlic (Allium ursinum L.) dried extract was used as an active compound because of its antimicrobial activity and green properties. This system has demonstrated pH-dependent release of extract and higher shear elastic modulus values than ordinary disc gels. A conducted study has given preliminary results for the possible application of bilayer chitosan-based hydrogels in wound dressing systems and represents the first step towards extrapolating the proposed design across other application fields.
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