Cooperative Gold/Zinc‐Catalyzed Cascade Approach to Tryptophan Derivatives from N‐arylhydroxylamines and Alkynes

Abstract A cooperative gold/zinc catalyzed strategy for the synthesis of tryptophan derivatives from easily prepared N ‐arylhydroxylamines and chiral amino acid tethered alkynes with high efficiency has been developed. The structurally diverse tryptophan derivatives including pharmaceutical relevant molecules can be readily prepared by this method. This tandem transformation starts from acyclic simple materials rather than the existing methods by modifying indole skeletons.