Nickel-Catalyzed Regioselective Reductive Ring Opening of Aryl Cyclopropyl Ketones with Alkyl Bromides

Herein, we report the successful implementation of reductive strategy in the ring opening reaction of aryl cyclopropyl ketones with unactivated alkyl bromides. Under the catalysis of nickel, this reductive Csp3–Csp3 cross-coupling reaction proceeds with complete regioselectivity and bypasses the use of pregenerated organometallics, enabling efficient synthesis of alkylated ketones with high step economy and functionality tolerance.