脂氧合酶
自噬
程序性细胞死亡
细胞凋亡
酶
生物
细胞生物学
细胞
疾病
脂质信号
生物化学
医学
病理
作者
Qiu-Qi Li,Li Qin,Ji-Ning Jia,Zhao‐Qian Liu,Hong‐Hao Zhou,Xiao‐Yuan Mao
标识
DOI:10.1016/j.neuint.2018.04.002
摘要
The 12/15-lipoxygenase (12/15-LOX) enzymes react with polyunsaturated fatty acids producing active lipid metabolites that are involved in plethora of human diseases including neurological disorders. A great many of elegant studies over the last decades have contributed to unraveling the mechanism how 12/15-lipoxygenase play a role in these diseases. And the way it works is mainly through apoptosis. However, recent years have found that the way 12/15-lipoxygenase works is also related to autophagy and ferroptosis, a newly defined type of cell death by Stockwell's lab in 2012. Figuring out how 12/15-lipoxygenase participate in these modes of cell death is of vital importance to understand its role in disease. The review aims to give a sight on our current knowledge on the role of this enzyme in apoptosis, autophagy and ferroptosis. And the relevant diseases that 12/15-lipoxygenase may be involved.
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