生物
趋化因子受体
趋化因子
亚科
CCL21型
趋化性
CCR1
受体
免疫学
CCR2型
神经科学
细胞生物学
免疫系统
遗传学
基因
作者
Alessandro Vacchini,Massimo Locati,Elena Monica Borroni
标识
DOI:10.1189/jlb.2mr1015-477r
摘要
Abstract Chemokines modulate immune responses through their ability to orchestrate the migration of target cells. Chemokines directly induce cell migration through a distinct set of 7 transmembrane domain G protein-coupled receptors but are also recognized by a small subfamily of atypical chemokine receptors, characterized by their inability to support chemotactic activity. Atypical chemokine receptors are now emerging as crucial regulatory components of chemokine networks in a wide range of physiologic and pathologic contexts. Although a new nomenclature has been approved recently to reflect their functional distinction from their conventional counterparts, a systematic view of this subfamily is still missing. This review discusses their biochemical and immunologic properties to identify potential unifying themes in this emerging family.
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