生物
转移
表观遗传学
间质细胞
癌细胞
癌症
癌症研究
癌症转移
肿瘤微环境
癌变
计算生物学
肿瘤进展
基因
遗传学
作者
Scott Valastyan,Robert A. Weinberg
出处
期刊:Cell
[Elsevier]
日期:2011-10-14
卷期号:147 (2): 275-292
被引量:2781
标识
DOI:10.1016/j.cell.2011.09.024
摘要
Metastases represent the end products of a multistep cell-biological process termed the invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically distant organ sites and their subsequent adaptation to foreign tissue microenvironments. Each of these events is driven by the acquisition of genetic and/or epigenetic alterations within tumor cells and the co-option of nonneoplastic stromal cells, which together endow incipient metastatic cells with traits needed to generate macroscopic metastases. Recent advances provide provocative insights into these cell-biological and molecular changes, which have implications regarding the steps of the invasion-metastasis cascade that appear amenable to therapeutic targeting.
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