微型多孔材料
介孔材料
等结构
多孔性
上部结构
对映体
化学工程
吸附
材料科学
对映选择合成
多孔介质
相(物质)
化学
色谱法
纳米技术
结晶学
有机化学
催化作用
晶体结构
地质学
工程类
海洋学
作者
Chengfeng Zhu,Ke-Ke Yang,Hongzhao Wang,Yu Fang,Liang Feng,Jiaqi Zhang,Zhifeng Xiao,Xiang Wu,Yougui Li,Yanming Fu,Wencheng Zhang,Kunyu Wang,Hong-Cai Zhou
出处
期刊:ACS central science
[American Chemical Society]
日期:2022-04-22
卷期号:8 (5): 562-570
被引量:6
标识
DOI:10.1021/acscentsci.1c01571
摘要
Efficient enantioselective separation using porous materials requires tailored and diverse pore environments to interact with chiral substrates; yet, current cage materials usually feature uniform pores. Herein, we report two porous assemblies, PCC-60 and PCC-67, using isostructural octahedral cages with intrinsic microporous cavities of 1.5 nm. The PCC-67 adopts a densely packed mode, while the PCC-60 is a hierarchically porous assembly featuring interconnected 2.4 nm mesopores. Compared with PCC-67, the PCC-60 demonstrates excellent enantioselectivity and recyclability in separating racemic diols and amides. This solid adsorbent PCC-60 is further utilized as a chiral stationary phase for high-performance liquid chromatography (HPLC), enabling the complete separation of six valuable pharmaceutical intermediates. According to quantitative dynamic experiments, the hierarchical pores facilitate the mass transfer within the superstructure, shortening the equilibrium time for adsorbing chiral substrates. Notably, this hierarchically porous material PCC-60 indicates remarkably higher enantiomeric excess (ee) values in separating racemates than PCC-67 with uniform microporous cavities. Control experiments confirm that the presence of mesopores enables the PCC-60 to separate bulky substrates. These results uncover the traditionally underestimated role of hierarchical porosity in porous-superstructure-based enantioseparation.
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